Variant of Uncertain Significance (VUS)
WEB2 days ago · Definition. 00:00. …. When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS). In many cases, these variants are so rare in the population that little information is available ...
What to do if your genetic test finds a variant of uncertain ...
WEBSep 29, 2021 · A VUS may also be reclassified as pathogenic, but this is rare. A recent study found that 91% of reclassified variants were downgraded to “benign,” while only 9% were upgraded to pathogenic. Reclassifying a VUS can take months, years or decades. Some may never be reclassified if labs don’t have enough data to draw a definitive …
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What Does Variant of Uncertain Significance (VUS) Mean?
WEBYou may get a variant of uncertain significance (VUS) result. This means the test found a mutation in one of the genes linked to inherited cancer, but it is not known if the mutation causes cancer. 1. It is difficult to determine exactly what the impact of many genetic mutations will be. Some mutations do not impact how a gene works and do not ...
WEBThe official report you get from a laboratory may use 5 classes to score genetic test results: Class 1. Not a disease causing change or variant. Sometimes called neutral or benign or polymorphism. Class 2. Suspected not to be disease causing. Class 3. Variants of Uncertain Significance (VUS). Class 4.
Variant of uncertain significance - Wikipedia
WEBA VUS is a common result in genetic testing. A variant of uncertain (or unknown) significance (VUS) is a genetic variant that has been identified through genetic testing but whose significance to the function or health of an organism is not known. [1] Two related terms are "gene of uncertain significance" (GUS), which refers to a gene that has ...