Sep 6, 2022 · In this article, we discuss recent advances of transcriptome analysis at single-cell levels that revealed a heretofore unanticipated close relationship between secretory MUC5AC and MUC5B …

MUC5B is expressed in the trachea, bronchi, and bronchioles, whereas MUC5AC expression is concentrated in relatively large airways, including the trachea and bronchi, but not in the distal …

To elucidate these biochemical changes, we used wild-type and CFTR-knockout (CFTR-KO) Calu3 cells to demonstrate that lack of CFTR function alone was sufficient to reduce ASL pH and increase the …

Nov 1, 2022 · MUC5B is expressed in the trachea, bronchi, and bronchioles, whereas MUC5AC expression is concentrated in relatively large airways, including the trachea and bronchi, but not in …

Apr 18, 2024 · In the absence of CFTR activity, abundant mucus accumulation, bacterial infection and inflammation characterize CF airways, in which inflammation-associated tissue remodeling and …

We find that MUC5B and MUC5AC deficiency results in im-paired and discoordinated mucociliary transport, respectively, demonstrating the importance of each mucin to airway clearance.

However, in neonatal wild-type and CF piglets, both Muc5ac and Muc5b mucins are expressed in goblet cells in the conducting airway epithelium, whereas Muc5b, but not Muc5ac, is expressed in glandular …

Jul 15, 2011 · The mucin concentration in airway secretions from CF subjects is similar to that for normal subjects until there is infection by P. aeruginosa, and after that, the mucin concentration decreases …

In this review, we discuss how CFTR malfunction can affect mucin biochemical interac-tions and alter the viscoelastic properties of mucus.

Jun 22, 2023 · MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues. Our objective was to qualify MUC5AC and MUC5B immunohistochemical techniques to …