Sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, has been shown to exert beneficial effects in heart failure. The purpose of this study was to test whether sildenafil suppressed transverse-tubule ...

Action potentials, with no accompanying contraction, were recorded from muscle fibers in which the transverse tubular system had been disrupted. The results show that action potentials require an ...

This study is concerned with the characterization of the morphology of the calcium release channel of sarcoplasmic reticulum (SR) from fast-twitch skeletal muscle, which is involved in ...

Researchers at Osaka University in Japan have identified specific genetic mutations that can cause dilated cardiomyopathy (DCM). In an article published in Science Translational Medicine entitled ...