Cognitive tasks, such as learning and memory, require rapid changes to proteins at synapses, such as protein synthesis, degradation, and trafficking. How protein post-translational modifications ...

Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

Scientists disclose how mitochondria control tissue rejuvenation and synaptic plasticity in the adult mouse brain. Nerve cells (neurons) are amongst the most complex cell types in our body. They ...

Memory formation and maintenance fundamentally rely on intricate molecular processes that regulate synaptic strength. Central to this phenomenon is synaptic plasticity – the capacity of neural ...

A study mapped genes linked to schizophrenia and uncovered a mechanism that disrupts synaptic plasticity in affected individuals. The researchers showed the role of three proteins in mediating the ...

Astrocytes use the MEGF10 receptor to prune synapses in the striatum, a process essential for dopamine-driven motor learning.

As animals experience new things, the connections between neurons, called synapses, strengthen or weaken in response to events and the activity they cause in the brain. Neuroscientists believe that ...

When we learn a new motor skill-whether mastering a piano passage or refining balance while walking-the brain must reorganize the circuits that ...

A structural protein best known for building the internal scaffolding of cells may double as a natural defense against the ...

Neurodegenerative disease profoundly affects structures and pathways responsible for memory, cognition, and higher-order ...

This mitochondrial process supports the brain cells essential to learning, memory and social recognition. We know that mitochondria are the powerhouses of the cell, but what role do they play in ...

By adding, removing, strengthening, or weakening synaptic contacts, our brain encodes new events or forgets previous ones. In AD, synaptic plasticity, the brain's ability to regulate the strength of ...