Autophagy is a process by which cells engulf and degrade their own damaged organelles and aggregated proteins. This self-cleaning feature is critical to the health of neurons, and its loss in the ...

New insights into a family of metabolites, acylspermidines, could change how we understand aging and fight disease. A new study presents an unexpected connection between spermidine, a long-known ...

PHILADELPHIA -- In recent years, scientists have learned that members of a family of enzymes known as sirtuins play critical roles in a wide array of vital life processes, including metabolism, aging, ...

Beyond all empty promises of miracle drugs, it has been clear for decades that there is indeed a simple way to extend lifespan, though not one that most people who have a choice are particularly ...

Jellyfish, sea sponges, amoebas and other animals on the early branches of the tree of life defy conventional aging. A new study reveals diversity of proteins called sirtuins in these animals compared ...

Study reveals that Sirtuin 7 regulates the functions of brown adipose tissue, thereby playing a critical role in overall energy regulation. Mammals convert the energy stored in adipose (fat) tissue ...

The gathering body of work focused a great deal of attention on sirtuins as the fabled 'fountain of youth.' Research groups began looking for evidence that sirtuins' longevity effects extended to ...

CAMBRIDGE, Mass. -- Aug 16, 2007 - Sirtris Pharmaceuticals, a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced today that ...

A study has uncovered a new strategy that can potentially treat age-related disease and decline. The report shows that restoring the activity of a class of enzymes called sirtuins with a small ...

Many people with Type 2 diabetes and obesity experience abnormal spikes in blood glucose, or hyperglycemia, following meals. It’s caused by abnormal glucose uptake in the liver, and it puts patients ...

A study led by researchers at Baylor College of Medicine has uncovered a new strategy that can potentially treat age-related disease and decline. The study, published in the journal Cell Metabolism, ...