Retinaldehyde, an intermediate metabolite between vitamin A and retinoic acid, is present at biologically active concentrations in fat tissue, where it antagonizes PPAR-γ activity, inhibiting ...

But the biggest knock on the beloved ingredient is that some people just can’t tolerate it, and for many others, there is an adjustment period during which your skin becomes dry and irritated. If you ...

Every product on this page was chosen by a Harper's BAZAAR editor. We may earn commission on some of the items you choose to buy. Retinol is a derivative of vitamin A, which also includes retinal (or ...

Figure 1: Aldh1a1 is present primarily in visceral fat, and its expression correlates with obesity. Figure 2: Aldh1a1 deficiency is characterized by increased transcription of brown fat markers in ...

The skincare benefits of retinol are numerous and well-known. From smoothing out fine lines to treating acne, it's a powerhouse ingredient for your skin. But with every benefit comes a downside, and ...

AKR1B10 is a human aldo-keto reductase (AKR) found to be elevated in several cancer types and in precancerous lesions. In vitro, AKR1B10 exhibits a much higher retinaldehyde reductase activity than ...

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