Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...

Leishmaniasis belongs to the class of neglected tropical diseases (NTDs) that particularly affect people in the poorest ...

The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

As one of the twenty-first century's most significant global health issues, the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has indeed altered our lives. Unlike ...

Cell membranes play a critical role by serving as containment units and separating the inner cellular space from the extracellular environment. Proteins with distinct functional units play a key role ...

Cancer thrives by hijacking the body's own basic survival systems, making it hard to attack tumors without collateral damage ...

It has long been thought that protein function and stability are highly sensitive to changes in the composition of the internal structures, or protein cores. However, a large-scale experiment probing ...