Diseases marked by progressive deterioration of the brain—neurodegeneration—have proven challenging to understand and treat. These common conditions affect millions of patients and families around the ...

In a recent perspective published in Cell Death Discovery, a group of authors critically evaluated and interpreted the evidence linking mitochondrial dysfunction and metabolic changes to the ...

Scientists from Northwestern University and elsewhere have published details of a study that links short strands of toxic RNAs to brain cell death and DNA damage in Alzheimer’s disease and aged brains ...

Gout, which is often referred to as hyperuricemia, is the most prevalent form of inflammatory arthritis, as it affects between 1% and 4% of the population. Gout is the result of monosodium urate ...

Smoking is widely known for its harmful effects on the lungs, but its effects go far beyond respiratory health. Smoking is ...

William McEwan, Ph.D., spent years unraveling how an antiviral protein, tripartite motif-containing 21 (TRIM21), protects our cells from infection. Working in the lab of Leo James, Ph.D., McEwan and ...

Pridopidine (45 mg twice daily) is a potent and selective, orally administered sigma-1 receptor (S1R) agonist which stimulates key neuroprotective mechanisms often impaired in neurodegenerative ...

Researchers have combined two sequencing technologies in single cells to find new differences in mRNAs resulting from Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease. Diseases ...