Major depressive disorder (MDD) is a prevalent and debilitating psychiatric disorder associated with high rates of suicide and significant family and social burdens [1, 2]. Nearly one-third of ...

The orbitofrontal cortex (OFC), a subsection of the brain's frontal lobe, is known to play a part in value-based decision-making, the process of mentally weighing the outcome of different decisions ...

As humans and other animals navigate their surroundings and experience different things, their brain creates so-called cognitive maps, which are internal representations of environments or tasks.

In a recent study published in the journal JCPP Advances, a group of researchers investigated whether early negative life events (NLEs) predict depressive symptoms in young adulthood through ...

A new study linked chronic pain to activity in the orbitofrontal cortex, an area involved in emotion regulation, self-evaluation and decision making. By Priyanka Runwal Researchers have for the first ...

Depression imposes a major global socioeconomic burden, and current pharmacotherapies face several limitations, including slow efficacy, adverse effects, and non-response rates of up to 55%, ...

Alcohol use disorder (AUD) is a life-threatening disease characterized by compulsive drinking, cognitive deficits, and social impairment that continue despite negative consequences. The inability of ...