Multiple sclerosis (MS) is a chronic autoimmune disease that targets mature oligodendrocytes (MOLs) and their myelin. MOLs are heterogeneous and can transition to immune-like states in MS. However, ...

MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in neuroinflammatory and neurodegenerative processes underlying multiple sclerosis (MS). This study aimed to identify candidate ...

A systematic review synthesises preclinical and human evidence that the choroid plexus drives immune infiltration, barrier disruption and genomic changes in multiple sclerosis.

The CD40–CD40L costimulatory pathway regulates adaptive and innate immune responses and has been implicated in the pathogenesis of multiple sclerosis. Frexalimab is a second-generation anti-CD40L ...

The body's immune response to Epstein-Barr virus (EBV) may play a role in causing damage in people with multiple sclerosis, according to a new study led by University of Texas Health Houston. EBV ...

Scientists uncover how shifts in gut fungi, shaped by genes and diet, may influence disease severity in people with multiple sclerosis, paving the way for new microbiome-based treatments. Study: ...

New findings reveal how a specific immune response to the Epstein-Barr virus could trigger multiple sclerosis, highlighting the intricate link between viral infection and autoimmune disease. Research ...

More research is necessary to understand cerebral oxygen consumption as a predictive biomarker for brain atrophy in multiple sclerosis (MS); however, this study found that mitochondrial dysfunction ...

A team of scientists from the New York Stem Cell Foundation (NYSCF) Research Institute and Case Western Reserve University has created the largest reported collection of stem cell models from multiple ...

"Medical Journeys" is a set of clinical resources reviewed by doctors, meant for physicians and other healthcare professionals as well as the patients they serve. Each episode of this journey through ...