Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

A new study from Karolinska Institutet, published in Nature Communications, reveals that cyclin-dependent kinases (CDK) promote DNA replication licensing in human cells by relieving inhibitory signals ...

Faithful replication of the genome is essential for development, tissue homeostasis and prevention of malignancy. Key steps in eukaryotic DNA replication include the licensing of replication origins, ...

Ribonucleotides are frequently misincorporated into DNA during replication, arising from imperfect sugar discrimination by DNA polymerases and high intracellular ribonucleotide triphosphate pools.

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

Genome-wide studies of fission yeast (Schizosaccharomyces pombe) suggest that the evolutionary conserved enzyme Pfh1 helicase facilitates DNA synthesis by tracking along with the replication apparatus ...

As recently as the mid-20th century, aging was described by Nobel Prize laureate Peter Medawar as "an unsolved problem in biology." Today, scientists can analyze the activity of thousands of genes in ...

Every human cell packs roughly two meters of DNA into a nucleus only six micrometers wide. That ratio, confirmed by ...