Isothermal titration calorimetry (ITC) provides a label-free and direct measure of the heat exchanged during molecular binding events, enabling a complete thermodynamic profile of noncovalent ...

Biochemical reactions are regulated by enzymes. These reactions involve binding, recognition, and the creation of non-covalent complexes. It is essential to characterize binding events in order to ...

Complexes, such as protein/protein, nucleic acids/nucleic acid, protein/nucleic acid, protein/ligand, nucleic acid/ligand, are often difficult to crystallize even on well-defined biological systems, ...

A new technique for measuring how quickly drugs interact with their molecular targets has been invented by a research team at McGill University. The technique is a new way to investigate the ...

MicroCal has introduced the new iTC200 Isothermal Titration Calorimeter using which researchers can achieve gold standard binding affinities with only 200 µl of sample. The iTC200 determines all ...

Measuring Enzyme Kinetic Parameters with the ITC Universal Enzyme Assay Method Enzymes are important in drug discovery and development since they constitute approximately one-half of all known drug ...

All biochemical reactions involve recognition, binding, and the formation of noncovalent complexes. Many small molecule drugs act by selectively binding to protein or nucleic acid targets and altering ...

Isothermal titration calorimetry (ITC) is one of the most robust and convenient techniques to thermodynamically examine intermolecular interactions by detecting any reaction heat that takes place in ...

Isothermal titration calorimetry and differential scanning calorimetry are valuable tools that can help accelerate drug development. Calorimetry is the science of measuring heat changes that result ...