Human immunodeficiency virus (HIV) infection has been transformed over the past two decades from a fatal to a chronic disease, because of combination antiretroviral therapy — a medical triumph. 1 ...
HIV treatment has improved over the past few decades. Many people living with HIV can now lead long, healthy lives by taking ...
Thought LeadersProfessor Kushol Gupta Research Assistant Professor University of Pennsylvania In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and ...
The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most common HIV strain. While symptoms can now be better managed with lifelong treatment, there is ...
The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most common HIV strain. While symptoms can now be better managed with lifelong treatment, there is ...
On the left is integrase in its “intasome” structure of four identical four-part complexes (pink) that connect to create one 16-part complex that locks around viral DNA (blue). On the right is ...
3TC: Lamivudine; ABC: Abacavir; DRV: Darunavir; DTG: Dolutegravir; EFV: Efavirenz; FTC: Emtricitabine; rtv: Ritonavir; TDF: Tenofovir. ↓: Decrease; ↑: Increase ...
HIV-1 integrase is the third enzymatic target of antiretroviral (ARV) therapy. However, few data have been published on the distribution of naturally occurring amino acid variation in this enzyme. We ...
Author(s)You J, Wang H, Huang X, et al. Therapy-emergent drug resistance to integrase strand transfer inhibitors in HIV-1 patients: a subgroup meta-analysis of clinical trials. PLoS One. 2016, ...
Globally, in 2020, 38 million people were living with HIV with an additional 1.5 million newly infected. During this period, 73% of those living with HIV were accessing antiretroviral therapy (WHO HIV ...
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