The University of Alabama at Birmingham

Nine new genomic regions that control a critical heart biomarker uncovered by largest genetic study

NT-proBNP is one of the most widely used tested biomarkers in medicine. Doctors rely on it to diagnose and monitor heart ...
Nature

Genome-wide interaction study of physical activity and genetic susceptibility on colorectal cancer using UK biobank data

Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide, accounting for 9.6% of all new cancer cases and 9.3% of all cancer deaths in 2022 1. Its ...
Nature

Detecting genetic interactions with visible neural networks

Non-linear interactions among single nucleotide polymorphisms (SNPs), genes, and pathways play an important role in human diseases, but identifying these interactions is a challenging task. Neural ...
Phys.org

Complex deep learning models are no better at understanding genetic perturbation than simple baseline ones, study finds

Deep learning models have shown great potential in predicting and engineering functional enzymes and proteins. Does this prowess extend to other fields of biology as well? Contrary to expectations, a ...
New Scientist

Huge study of Alzheimer’s genetics identifies new drug targets

Almost 50 more genes have been flagged as being linked to Alzheimer’s, along with changes in activity in crucial cells that ...
Medical Xpress

Same genetic mutation, different clinical outcomes: Study shows why neurodevelopmental disorders vary so widely

Individuals that share the same deletion of a portion of chromosome 16 are at risk of developing neurodevelopmental disorders, but some experience severe intellectual disability or developmental delay ...