The body has an intricate system to defend against infections where each type of immune cell plays a distinct role. Now, a study led by researchers from the Penn State College of Medicine has ...

One receptor can protect antibodies from degradation, extend their half-life and become a drug target itself. Explore the ...

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

Deleting a single amino acid (Pro230) in the lower hinge produced half-IgG1 molecules with disrupted disulfide bonds and reoriented Fab and Fc regions, highlighting the hinge’s essential role in ...

An international research team has identified a previously overlooked factor that influences how antibodies neutralize SARS-CoV-2: their mechanical stability under force. Antibodies are key components ...

Antibodies can improve the rehabilitation of people with acute spinal cord injury. Researchers at 13 clinics in Germany, Switzerland, the Czech Republic and Spain have investigated this with promising ...

The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single ...

High levels of thyroid antibodies indicate an autoimmune condition affecting the thyroid gland. Thyroid peroxidase antibodies (TPOAbs) and thyrotropin receptor antibodies (TRAbs) may signal autoimmune ...

b) an Fc domain comprising amino acid substitutions M428L/N434S as compared to a human Fc polypeptide, wherein numbering is according to the EU index of Kabat, wherein said anti-C5 antibody with said ...