Chemists want to trick cancer cells into taking up drug molecules by attaching the payloads to fatty acids. These cells grow rapidly compared to normal cells and they recognize fatty acids as ...
PHILADELPHIA – A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results ...
Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation
Fig. 3: DSS-induced ulcerative colitis in Baat −/− KO mice supplemented with 0.3% taurine-conjugated cholic acid modifies microbiome, metabolome and bile acid profiles. Fig. 4: Conjugated cholic acids ...
How did you discover MCBAs? Bile acids were first described chemically in 1849, and Heinrich Wieland was awarded a Nobel Prize in 1927 for comprehensively describing their chemistry. This description ...
Local excision and selective radical resection after neoadjuvant chemoradiation for rectal cancer. This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I. This abstract does not include ...
Some people claim that conjugated linoleic acid (CLA), a type of fatty acid, can be taken as a supplement to aid weight loss. However, human studies have not proved its efficacy or safety. Animal ...
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