A UPS cargo plane crashed at a Louisville, Kentucky, airport where the company operates its largest package delivery hub. UPS calls the giant center Worldport.

Multiple agencies are responding to a plane crash at the Louisville Muhammad Ali International Airport (SDF) Tuesday night, according to the Louisville Metro Police Department (LMPD). Injuries have been reported in the crash but no further information on the nature of those injuries or the victims has been immediately provided.

Officials say at least seven people were killed after a UPS plane crashed during takeoff at the Muhammad Ali International Airport in Louisville, Kentucky. NBC News’ Tom Costello has the details.

LOUISVILLE, Ky. -- A UPS cargo plane crashed and exploded in a massive fireball while taking off from the company’s global aviation hub in Louisville, Kentucky, killing at least seven people and injuring 11, authorities said.

Video shows massive fireball and smoke after UPS Flight 2976 crashed into Kentucky Petroleum Recycling building during takeoff at Louisville airport.

The transportation company's recent results demonstrated progress toward its underlying objective of shifting to higher-margin deliveries.

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