H OUSTON -- According to C.J. Stroud, he's one of the best quarterbacks in the NFL when he's dealing. And against the San Francisco 49ers, Stroud delivered what coach DeMeco Ryans called one of Stroud's "best games ever" in the Houston Texans ' 26-15 win Sunday.

Houston coach DeMeco Ryans had high praise for C.J. Stroud after his performance in Sunday's win over San Francisco. “One of his best games ever,” Ryans said. Stroud threw for a season-high 318 yards and two touchdowns to lead the Texans to the 26-15 victory.

Follow along with Texans Wire from kickoff to close as the Texans look to return to their winning ways over the San Francisco 49ers.

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

Houston Texans quarterback C.J. Stroud rips a 44-yard deep crossing-route pass to wide receiver Jaylin Noel against the San Francisco 49ers.

Oct 20, 2025; Seattle, Washington, USA; Houston Texans quarterback C.J. Stroud (7) runs onto the field for warmups prior to the game against the Seattle Seahawks at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images / Kevin Ng-Imagn Images